Longitudinal analyses reveal immunological misfiring in severe COVID-19.

ABSTRACT: Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)^1-4. However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analysed immune responses in 113 patients with moderate or severe COVID-19. Immune profiling revealed an overall increase in innate cell lineages, with a concomitant reduction in T cell number. An early elevation in cytokine levels was associated with worse disease outcomes. Following an early increase in cytokines, patients with moderate COVID-19 displayed a progressive reduction in type 1 (antiviral) and type 3 (antifungal) responses. By contrast, patients with severe COVID-19 maintained these elevated responses throughout the course of the disease. Moreover, severe COVID-19

SUBMITTER: Lucas C 

PROVIDER: S-EPMC7477538 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature