Language disturbances in schizophrenia: the relation with antipsychotic medication.

ABSTRACT: Language disturbances are key aberrations in schizophrenia. Little is known about the influence of antipsychotic medication on these symptoms. Using computational language methods, this study evaluated the impact of high versus low dopamine D₂ receptor (D2R) occupancy antipsychotics on language disturbances in 41 patients with schizophrenia, relative to 40 healthy controls. Patients with high versus low D2R occupancy antipsychotics differed by total number of words and type-token ratio, suggesting medication effects. Both patient groups differed from the healthy controls on percentage of time speaking and clauses per utterance, suggesting illness effects. Overall, more severe negative language disturbances (i.e. slower articulation rate, increased pausing, and shorter utterances

SUBMITTER: de Boer JN 

PROVIDER: S-EPMC7477551 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature