Role of mesenchymal stem cell derived extracellular vesicles in autoimmunity: A systematic review.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) have been reported to possess immune regulatory effects in innate and adaptive immune reactions. MSCs can mediate intercellular communications by releasing extracellular vesicles (EVs), which deliver functional molecules to targeted cells. MSC derived EVs (MSC-EVs) confer altering effects on many immune cells, including T lymphocytes, B lymphocytes, natural killer cells, dendritic cells, and macrophages. A large number of studies have suggested that MSC-EVs participate in regulating autoimmunity related diseases. This characteristic of MSC-EVs makes them be potential biomarkers for the diagnosis and treatment of autoimmunity related diseases.

Aim

To verify the potential of MSC-EVs for molecular targeted therapy of autoimmunity related

SUBMITTER: Wang JH 

PROVIDER: S-EPMC7477661 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature