Concurrent chemoradiation for cervical cancer: Comparison of LDR and HDR brachytherapy.

ABSTRACT:

Purpose

To compare clinical outcomes between low-dose-rate (LDR) brachytherapy and high-dose-rate (HDR) brachytherapy for cervical cancer patients.

Methods and materials

All consecutive newly diagnosed cervical cancer patients undergoing pretreatment 18-fluorodeoxyglucose positron emission tomography imaging and treated with curative-intent definitive chemoradiation from 1997 to 2016 at a U.S. academic center were included. Brachytherapy boost was LDR or HDR 2D treatment planning from 1997 to 2005 and HDR with MR-based 3D planning from 2005 to 2016. Local control (LC), cancer-specific survival (CSS), and late bowel/bladder complications were evaluated.

Results

Tumor stages were International Federation of Gynecology and Obstetrics IB1-IIB (n = 457; 75%) and III-IVA (n

SUBMITTER: Lin AJ 

PROVIDER: S-EPMC7477730 | biostudies-literature | 2019 May - Jun

REPOSITORIES: biostudies-literature