Genetically Determined Levels of Circulating Cytokines and Risk of Stroke.

ABSTRACT:

Background

Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown associations of their circulating levels with stroke. Our objective was to explore whether genetically determined circulating levels of cytokines and growth factors are associated with stroke and its etiologic subtypes by conducting a 2-sample Mendelian randomization (MR) study.

Methods

Genetic instruments for 41 cytokines and growth factors were obtained from a genome-wide association study of 8293 healthy adults. Their associations with stroke and stroke subtypes were evaluated in the MEGASTROKE genome-wide association study data set (67 162 cases; 454 450 controls) applying inverse variance-weighted meta-analysis, weighted-me

SUBMITTER: Georgakis MK 

PROVIDER: S-EPMC7477819 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature