Subtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 Controls.

ABSTRACT:

Background

Genome-wide association studies have identified multiple loci associated with stroke. However, the specific stroke subtypes affected, and whether loci influence both ischemic and hemorrhagic stroke, remains unknown. For loci associated with stroke, we aimed to infer the combination of stroke subtypes likely to be affected, and in doing so assess the extent to which such loci have homogeneous effects across stroke subtypes.

Methods

We performed Bayesian multinomial regression in 16 664 stroke cases and 32 792 controls of European ancestry to determine the most likely combination of stroke subtypes affected for loci with published genome-wide stroke associations, using model selection. Cases were subtyped under 2 commonly used stroke classification systems, TOAST (T

SUBMITTER: Traylor M 

PROVIDER: S-EPMC7477820 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature