Esophageal Histological Precursor Lesions and Subsequent 8.5-Year Cancer Risk in a Population-Based Prospective Study in China.

ABSTRACT:

Introduction

Data on the associations between esophageal histological lesions and risk of esophageal squamous cell carcinoma (ESCC) in general populations are limited. We aimed to investigate these associations in a large Chinese general population to inform future Chinese ESCC screening guidelines.

Methods

We performed endoscopic screening of 21,111 participants aged 40-69 years from 3 high-risk areas of China in 2005-2009, and followed the cohort through 2016. Cumulative incidence and mortality rates of ESCC were calculated by baseline histological diagnosis, and hazard ratios of ESCC, overall and by age and sex, were assessed using the Cox proportional hazards models.

Results

We identified 143 new ESCC cases (0.68%) and 62 ESCC deaths (0.29%) during a median follow

SUBMITTER: Wei WQ 

PROVIDER: S-EPMC7477846 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature