Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching.

ABSTRACT:

Background

Excessive inflammation within damaged tissue usually leads to delayed or insufficient regeneration, and nerves in the peripheral nervous system (PNS) generally do not recover fully following damage. Consequently, there is growing interest in whether modulation of the inflammatory response could help to promote nerve regeneration in the PNS. However, to date, there are no practical therapeutic strategies for manipulating inflammation after nerve injury. Thrombomodulin (TM) is a transmembrane glycoprotein containing five domains. The lectin-like domain of TM has the ability to suppress the inflammatory response. However, whether TM can modulate inflammation in the PNS during nerve regeneration has yet to be elucidated.

Methods

We investigated the role of TM in switc

SUBMITTER: Huang TC 

PROVIDER: S-EPMC7477856 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature