Analysis of maternal and perinatal determinants of allergic sensitization in childhood.

ABSTRACT:

Background

Non-communicable diseases, such as allergies, are influenced by both genetic and epigenetic factors. Perinatal determinants conceivably modify the epigenetic makeup of the developing fetal immune system preventing or predisposing the development of allergies. The aim of this study therefore was to identify independent perinatal factors associated with allergic sensitization in childhood.

Methods

In a single center retrospective case-cohort study electronic obstetric medical records and available skin prick testing results of children were analyzed. For the analysis 286 skin prick test positive (sensitized) children [median (IQR): 3.47 (1.70-7.34) years] were compared with data from all remaining live births in the obstetric cohort (n = 66,583).

Results

Sens

SUBMITTER: Schafer S 

PROVIDER: S-EPMC7477859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature