MCC-SP: a powerful integration method for identification of causal pathways from genetic variants to complex disease.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have successfully identified genetic susceptible variants for complex diseases. However, the underlying mechanism of such association remains largely unknown. Most disease-associated genetic variants have been shown to reside in noncoding regions, leading to the hypothesis that regulation of gene expression may be the primary biological mechanism. Current methods to characterize gene expression mediating the effect of genetic variant on diseases, often analyzed one gene at a time and ignored the network structure. The impact of genetic variant can propagate to other genes along the links in the network, then to the final disease. There could be multiple pathways from the genetic variant to the final disease, with each having the cha

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7477886 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature