Evaluation of the FilmArray^® Pneumonia Plus Panel for Rapid Diagnosis of Hospital-Acquired Pneumonia in Intensive Care Unit Patients.

ABSTRACT: The FilmArray^® Pneumonia plus Panel (FAPP) is a new multiplex molecular test for hospital-acquired pneumonia (HAP), which can rapidly detect 18 bacteria, 9 viruses, and 7 resistance genes. We aimed to compare the diagnosis performance of FAPP with conventional testing in 100 intensive care unit (ICU) patients who required mechanical ventilation, with clinically suspected HAP. A total of 237 samples [76 bronchoalveolar lavages (BAL_DS) and 82 endotracheal aspirates (ETA_DS) obtained at HAP diagnosis, and 79 ETA obtained during follow-up (ETA_TT)], were analyzed independently by routine microbiology testing and FAPP. 58 patients had paired BAL_DS and ETA_DS. The positivity thresholds of semi-quantified bacteria were 10³

SUBMITTER: Cremet L 

PROVIDER: S-EPMC7477898 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature