BCR selection and affinity maturation in Peyer's patch germinal centres.

ABSTRACT: The antigen-binding variable regions of the B cell receptor (BCR) and of antibodies are encoded by exons that are assembled in developing B cells by V(D)J recombination¹. The BCR repertoires of primary B cells are vast owing to mechanisms that create diversity at the junctions of V(D)J gene segments that contribute to complementarity-determining region 3 (CDR3), the region that binds antigen¹. Primary B cells undergo antigen-driven BCR affinity maturation through somatic hypermutation and cellular selection in germinal centres (GCs)^2,3. Although most GCs are transient³, those in intestinal Peyer's patches (PPs)-which depend on the gut microbiota-are chronic⁴, and little is known about their BCR repertoires or patterns of somatic hyperm

SUBMITTER: Chen H 

PROVIDER: S-EPMC7478071 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature