Myelin water fraction estimation using small-tip fast recovery MRI.

ABSTRACT:

Purpose

To demonstrate the feasibility of an optimized set of small-tip fast recovery (STFR) MRI scans for rapidly estimating myelin water fraction (MWF) in the brain.

Methods

We optimized a set of STFR scans to minimize the Cramér-Rao Lower Bound of MWF estimates. We evaluated the RMSE of MWF estimates from the optimized scans in simulation. We compared STFR-based MWF estimates (both modeling exchange and not modeling exchange) to multi-echo spin echo (MESE)-based estimates. We used the optimized scans to acquire in vivo data from which a MWF map was estimated. We computed the STFR-based MWF estimates using PERK, a recently developed kernel regression technique, and the MESE-based MWF estimates using both regularized non-negative least squares (NNLS) and PERK.

Results

SUBMITTER: Whitaker ST 

PROVIDER: S-EPMC7478173 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature