Defining Extreme Phenotypes of OSA Across International Sleep Centers.

ABSTRACT:

Background

Extreme phenotypes of OSA have not been systematically defined.

Research question

This study developed objective definitions of extreme phenotypes of OSA by using a multivariate approach. The utility of these definitions for identifying characteristics that confer predisposition toward or protection against OSA is shown in a new prospective sample.

Study design and methods

In a large international sample, race-specific liability scores were calculated from a weighted logistic regression that included age, sex, and BMI. Extreme cases were defined as individuals with an apnea-hypopnea index (AHI) ≥ 30 events/hour but low likelihood of OSA based on age, sex, and BMI (liability scores > 90th percentile). Similarly, extreme controls were individuals with an AHI 

SUBMITTER: Rizzatti FG 

PROVIDER: S-EPMC7478234 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature