Imaging Fast-Acting Drug Effects in Humans Using ¹H-MRS.

ABSTRACT: Proton magnetic spectroscopy (¹H-MRS) is a noninvasive imaging technique that allows for the quantification of neurometabolic compounds at millimolar concentrations in the living human brain. This technique has been most often used to assess long-term changes in human brain metabolism in psychiatric disorders, pharmacological treatment, chronic drug use, and alcohol dependence. In contrast, the capacity of ¹H-MRS to evaluate the biochemical changes in the minutes to hours following drug consumption, which contribute to fast-acting drug-induced changes in perception, mood, cognition, and behavior, is largely unexplored. This Viewpoint highlights the utility of ¹H-MRS imaging for revealing neural mechanisms of rapid drug action in the human brain, with implic

SUBMITTER: White TL 

PROVIDER: S-EPMC7478238 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature