Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.

ABSTRACT: Botulinum neurotoxin serotype A (BoNT/A), marketed commercially as Botox, is the most toxic substance known to man with an estimated intravenous lethal dose (LD₅₀) of 1-2 ng/kg in humans. Despite its widespread use in cosmetic and medicinal applications, no postexposure therapeutics are available for the reversal of intoxication in the event of medical malpractice or bioterrorism. Accordingly, the Centers for Disease Control and Prevention categorizes BoNT/A as a Category A pathogen, posing the highest risk to national security and public health as a result of the ease with which BoNT/A can be weaponized and disseminated. BoNT/A-mediated lethality results from neurons impeded from releasing acetylcholine, which ultimately causes muscle paralysis and possible death by asphyxiatio

SUBMITTER: Lin L 

PROVIDER: S-EPMC7478247 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature