The prognostic significance of nodal disease burden in patients with lymph node metastases from renal cell carcinoma.

ABSTRACT: OBJECTIVES:To assess the relationship between nodal disease burden and overall survival (OS) among patients with lymph node (LN) metastases from renal cell carcinoma (RCC) METHODS: The National Cancer Data Base was used to identify 2,975 patients with RCC who were treated with radical nephrectomy and were found to have regional LN metastases. Associations between the number of positive and negative LN removed and OS were assessed using Cox proportional hazards regression. The median follow-up time among survivors was 3.6years. RESULTS:The median number of positive LN was 1 (interquartile range 1-3). A higher number of positive LN was associated with higher all-cause mortality on multivariable analysis (HR 1.06 per 1 positive LN, 95% CI 1.04, 1.07, P < 0.001). Conversely, higher negative LN

SUBMITTER: Zareba P 

PROVIDER: S-EPMC7478336 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature