Liraglutide and Insulin Have Contrary Effects on Adipogenesis of Human Adipose-Derived Stem Cells via Wnt Pathway.

ABSTRACT:

Background

Glucagon-like peptide-1 (GLP-1) has been reported to have beneficial impacts on improving human's metabolism and ameliorating insulin resistance. While insulin is another important and conventional drug in diabetes treatment, but it has an adverse effect on weight gain.

Purpose

To make sure whether GLP-1 and insulin play different roles in human adipose-derived stem cells (hADSCs).

Methods

We examined the in vitro roles and molecular mechanisms of liraglutide, a GLP-1 analogue, and human insulin on hADSCs isolated from subcutaneous adipose tissue. Different concentrations (0, 0.1, 1, 10, 100nM) of liraglutide and insulin were added to proliferation and differentiation medium of hADSCs, respectively.

Results

Liraglutide inhibits while insulin promotes

SUBMITTER: Liu H 

PROVIDER: S-EPMC7478378 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature