Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis.

ABSTRACT:

Objective

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) near the melanocortin 4 receptor (MC4R), gene which are associated with risk of obesity. Since obesity is an established risk factor of cancer, several studies have examined the association between SNPs near the MC4R gene and cancer risk, but the findings are inconsistent. The present study aimed to perform a meta-analysis to clarify the association between SNPs near MC4R and cancer risk.

Methods

The PubMed and Embase databases were searched for potentially eligible publications. All studies that evaluated the association between MC4R rs17782313 SNP (or its proxy rs12970134) and cancer risk were included. The pooled odds ratios with 95% confidence intervals (CIs) were calculated

SUBMITTER: Zeng T 

PROVIDER: S-EPMC7478401 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature