Whether statin use improves the survival of patients with glioblastoma?: A meta-analysis.

ABSTRACT: BACKGROUND:Glioblastomas are malignant brain tumors associated with high mortality and poor prognosis. Evidence from preclinical studies suggests that statins have an antitumor role, but their effects on the survival of patients with glioblastoma remain controversial. This meta-analysis attempts to assess the association between statins and glioblastoma. METHODS:We searched 4 databases (PubMed, Web of Science, Embase, and Cochrane Library) for articles that evaluate the effect of statins on the survival of patients with glioblastoma. Two reviewers were asked to assess the quality of the studies and extract the data regarding progression-free survival (PFS) and overall survival (OS). RESULT:A total of 5 studies met the inclusion criteria with 430 statin users and 2089 nonstatin users. All 5

SUBMITTER: Xie Y 

PROVIDER: S-EPMC7478415 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature