Dose-response association of resting heart rate and hypertension in adults: A systematic review and meta-analysis of cohort studies.

ABSTRACT:

Background

The association of resting heart rate (RHR) and hypertension in adults is unclear. We aimed to perform a meta-analysis of cohort studies to clarify the association.

Methods

We searched PubMed and Embase from their inception to November 3, 2017, for published articles. We used a random effects model to combine study-specific relative risks (RRs) and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relationship.

Results

Nine cohort articles (12 independent studies) with 79,399 individuals and more than 26,380 incident cases of hypertension were included. The summary RR for hypertension was 1.09 (95% CI: 1.06-1.13) with each 10 bpm increment in RHR. The cubic spline model suggested that when compared with 55

SUBMITTER: Shen L 

PROVIDER: S-EPMC7478507 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature