Association of polymorphisms of preptin, irisin and adropin genes with susceptibility to coronary artery disease and hypertension.

ABSTRACT:

Objectives

Preptin, irisin and adropin are 3 new players in energy regulation that are related body mass index, lipids, glucose and insulin levels which may affect incidence of cardiovascular diseases. The aim of the present study was to evaluate eight single nucleotide polymorphisms (SNPs) of preptin genes (rs1003483, rs1004446, rs2239681, rs680, and rs3741204), irisin (rs16835198 and rs3480) and adropin (rs2281997) gene in patients with coronary artery disease (CAD) and hypertension.

Methods

This case-control study was carried out on 372 volunteers, which were divided into 3 subgroups including: CAD patients with hypertension (CAD+H+), CAD patients with no hypertension (CAD+H-), and non-hypertensive non-CAD subjects as control group (CAD-H-) as health control. Genomic DNA

SUBMITTER: Wang H 

PROVIDER: S-EPMC7478509 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature