Ontology highlight
ABSTRACT:
SUBMITTER: Mahuron KM
PROVIDER: S-EPMC7478725 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200901 9
Tumor-infiltrating CD8+ T cells mediate antitumor immune responses. However, the mechanisms by which T cells remain poised to kill cancer cells despite expressing high levels of inhibitory receptors are unknown. Here, we report that layilin, a C-type lectin domain-containing membrane glycoprotein, is selectively expressed on highly activated, clonally expanded, but phenotypically exhausted CD8+ T cells in human melanoma. Lineage-specific deletion of layilin on murine CD8+ T cells reduced their a ...[more]