Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC7478730 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200901 9
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2 impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of amyloid β (Aβ) accumulation, defective TREM2 function affects microglial response to Aβ plaques, exacerbating tissue damage, whereas TREM2 overexpression attenuates pathology. Thus, AD may benefit from TREM2 activation. Here, we examined the impact of an anti-human TREM2 agonistic mAb, AL002c, in a mouse AD model expressing ...[more]