Information transmission from NFkB signaling dynamics to gene expression.

ABSTRACT: The dynamic signal encoding paradigm suggests that information flows from the extracellular environment into specific signaling patterns (encoding) that are then read by downstream effectors to control cellular behavior. Previous work empirically quantified the information content of dynamic signaling patterns. However, whether this information can be faithfully transmitted to the gene expression level is unclear. Here we used NFkB signaling as a model to understand the accuracy of information transmission from signaling dynamics into gene expression. Using a detailed mathematical model, we simulated realistic NFkB signaling patterns with different degrees of variability. The NFkB patterns were used as an input to a simple gene expression model. Analysis of information transmission between

SUBMITTER: Maity A 

PROVIDER: S-EPMC7478807 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature