Feasibility and first reports of the MATCH-R repeated biopsy trial at Gustave Roussy.

ABSTRACT: Unravelling the biological processes driving tumour resistance is necessary to support the development of innovative treatment strategies. We report the design and feasibility of the MATCH-R prospective trial led by Gustave Roussy with the primary objective of characterizing the molecular mechanisms of resistance to cancer treatments. The primary clinical endpoints consist of analyzing the type and frequency of molecular alterations in resistant tumours and compare these to samples prior to treatment. Patients experiencing disease progression after an initial partial response or stable disease for at least 24 weeks underwent a tumour biopsy guided by CT or ultrasound. Molecular profiling of tumours was performed using whole exome sequencing, RNA sequencing and panel sequencing. At data cut

SUBMITTER: Recondo G 

PROVIDER: S-EPMC7478969 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature