IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon.

ABSTRACT: The physiological stresses that diminish tissue stem-cell characteristics remain largely unknown. We previously reported that type I interferon (IFN), which is essential for host antiviral responses, is a physiological stressor for hematopoietic stem cells (HSCs) and small intestinal stem cells (ISCs) and that interferon regulatory factor-2 (IRF2), which attenuates IFN signaling, maintains their stemness. Here, using a dextran sodium sulfate (DSS)-induced colitis model, we explore the role of IRF2 in maintaining colonic epithelial stem cells (CoSCs). In mice with a conditional Irf2 deletion in the intestinal epithelium (hereafter Irf2^ΔIEC mice)_, both the number and the organoid-forming potential of CoSCs were markedly reduced. Consistent with this finding, the ability

SUBMITTER: Minamide K 

PROVIDER: S-EPMC7479133 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature