Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study.

ABSTRACT: Small-scale studies have suggested a link between the human gut microbiome and highly prevalent diseases. However, the extent to which the human gut microbiome can be considered a determinant of disease and healthy aging remains unknown. We aimed to determine the spectrum of diseases that are linked to the human gut microbiome through the utilization of its genetic determinants as a proxy for its composition. 180 single nucleotide polymorphisms (SNPs) known to influence the human gut microbiome were used to assess the association with health and disease outcomes in 422,417 UK Biobank participants. Potential causal estimates were obtained using a Mendelian randomization (MR) approach. From the total sample analysed (mean age was 57 ± 8 years), 194,567 (46%) subjects were male. Median exposu

SUBMITTER: Groot HE 

PROVIDER: S-EPMC7479141 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature