The precursor of PI(3,4,5)P₃ alleviates aging by activating daf-18(Pten) and independent of daf-16.

ABSTRACT: Aging is characterized by the loss of homeostasis and the general decline of physiological functions, accompanied by various degenerative diseases and increased rates of mortality. Aging targeting small molecule screens have been performed many times, however, few have focused on endogenous metabolic intermediates-metabolites. Here, using C. elegans lifespan assays, we conducted a worm metabolite screen and identified an eukaryotes conserved metabolite, myo-inositol (MI), to extend lifespan, increase mobility and reduce fat content. Genetic analysis of enzymes in MI metabolic pathway suggest that MI alleviates aging through its derivative PI(4,5)P₂. MI and PI(4,5)P₂ are precursors of PI(3,4,5)P₃, which is negatively related to longevity. The longevity effec

SUBMITTER: Shi D 

PROVIDER: S-EPMC7479145 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature