Integration of molecular profiles in a longitudinal wellness profiling cohort.

ABSTRACT: An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong un

SUBMITTER: Tebani A 

PROVIDER: S-EPMC7479148 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature