Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis.

ABSTRACT: Osteoporosis is characterized by decreased bone mineral density and increased risk of fracture. Raloxifene is one of the treatments of osteoporosis. However, the responses were variable among patients. Previous studies revealed that the genetic variants are involved in the regulation of treatment outcomes. To date, studies that evaluate the influence of genes across all genome on the raloxifene treatment response are still limited. In this study, a total of 41 postmenopausal osteoporosis patients under regular raloxifene treatment were included. Gene-based analysis using MAGMA was applied to investigate the genetic association with the bone mineral density response to raloxifene at the lumbar spine or femoral neck site. Results from gene-based analysis indicated several genes (GHRHR

SUBMITTER: Lu HF 

PROVIDER: S-EPMC7479487 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature