Biophysical characterization dataset of native nicotinic acetylcholine receptor in lipid-like detergent complexes.

ABSTRACT: For a long time, traditional purification and extraction methods for the native Torpedo californica nicotinic acetylcholine receptor in lipid-like detergent complex (nAChR-DC) have compromised its purity, functionality and X-ray structural studies possibility. The dataset presented in this article provide a characterization of the Torpedo californica nAChR-DC purified using a sequential purification processes developed in our laboratory [1]. This purification takes in consideration all of the physicochemical and functional requirements stablished by several researchers for the past three decades for the nAChR. These requirements were addressed in order to preserve the stability and functionality of nAChR-DC while ensuring the highest degree of protein purity. We focused on th

SUBMITTER: Maldonado-Hernandez R 

PROVIDER: S-EPMC7479489 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature