Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance.

ABSTRACT: Chronic stress is a key risk factor for mood disorders like depression, but the stress-induced changes in brain circuit function and gene expression underlying depression symptoms are not completely understood, hindering development of novel treatments. Because of its projections to brain regions regulating reward and anxiety, the ventral hippocampus is uniquely poised to translate the experience of stress into altered brain function and pathological mood, though the cellular and molecular mechanisms of this process are not fully understood. Here, we use a novel method of circuit-specific gene editing to show that the transcription factor ΔFosB drives projection-specific activity of ventral hippocampus glutamatergic neurons causing behaviorally diverse responses to stress. We establish mol

SUBMITTER: Eagle AL 

PROVIDER: S-EPMC7479591 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature