Ontology highlight
ABSTRACT:
SUBMITTER: Kang Y
PROVIDER: S-EPMC7479609 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kang Yi Y Nasr Marjan M Guo Yiru Y Uchida Shizuka S Weirick Tyler T Li Hong H Kim Jae J Moore Joseph B JB Muthusamy Senthilkumar S Bolli Roberto R Wysoczynski Marcin M
Scientific reports 20200908 1
Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration-suggesting a paracrine-mediated mechanism of action. As the immune system is inextricably linked to wound healing/remodeling in the ischemically injured heart, the reparative actions of CMCs may be attributed to their immunoregulatory proper ...[more]