Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice.

ABSTRACT: Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration-suggesting a paracrine-mediated mechanism of action. As the immune system is inextricably linked to wound healing/remodeling in the ischemically injured heart, the reparative actions of CMCs may be attributed to their immunoregulatory properties. The current study evaluated the consequences of CMC administration on post myocardial infarction (MI) immune responses in vivo and paracrine-mediated immune cell function in vitro. CMC administration preferentially elicited the recruitment of cell types associated with innate immunity (e.g., m

SUBMITTER: Kang Y 

PROVIDER: S-EPMC7479609 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature