Defective development and microcirculation of intestine in Npr2 mutant mice.

ABSTRACT: Intractable gastrointestinal (GI) diseases often develop during infancy. Our group previously reported that natriuretic peptide receptor B (NPR-B)-deficient Npr2^slw/slw mice exhibit severe intestinal dysfunction, such as stenosis and distention, which resembles the dysfunction observed in Hirschsprung's disease-allied disorders. However, the root cause of intestinal dysfunction and the detailed of pathophysiological condition in the intestine are not yet clear. Here, we report that the intestine of preweaning Npr2^slw/slw mice showed bloodless blood vessels, and nodes were found in the lymphatic vessel. Additionally, the lacteals, smooth muscle, blood vessel, and nerves were barely observed in the villi of preweaning Npr2^slw/slw mice. Moreover, intramuscular

SUBMITTER: Sogawa-Fujiwara C 

PROVIDER: S-EPMC7479618 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature