Impact of Age on Plasma Inflammatory Biomarkers in the 6 Months Following Mild Traumatic Brain Injury.

ABSTRACT:

Objective

To compare plasma inflammatory biomarker concentrations to 6 months in young and older adults with and without mild traumatic brain injury (TBI).

Setting

Level 1 trauma center.

Participants

Younger (21-54 years) and older (55+) adults diagnosed with mild TBI along with age-/sex-matched noninjured controls (n = 313).

Design

Prospective cohort study.

Main measures

Multiplex assays were used to quantify concentrations of selected plasma inflammatory markers at day 0, months 1 and 6.

Results

Persistent aging-related differences were found between control groups in concentrations of 4 cytokines up to 6 months. At day 0, interleukin-6 (IL-6), IL-8, and fractalkine were higher in the older TBI compared with older control as well as the younger

SUBMITTER: Thompson HJ 

PROVIDER: S-EPMC7479638 | biostudies-literature | 2020 Sep/Oct

REPOSITORIES: biostudies-literature