White Matter Hyperintensities Contribute to Language Deficits in Primary Progressive Aphasia.

ABSTRACT:

Objective

To determine the contribution of white matter hyperintensities (WMH) to language deficits while accounting for cortical atrophy in individuals with primary progressive aphasia (PPA).

Method

Forty-three individuals with PPA completed neuropsychological assessments of nonverbal semantics, naming, and sentence repetition plus T2-weighted and fluid-attenuated inversion recovery scans. Using three visual scales, we rated WMH and cerebral ventricle size for both scan types. We used Spearman correlations to evaluate associations between the scales and scans. To test whether visual ratings-particularly of WMH-are associated with language, we compared a base model (including gray matter component scores obtained via principal component analysis, age, and days between assess

SUBMITTER: Meier EL 

PROVIDER: S-EPMC7479763 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature