Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock.

ABSTRACT:

Key points

Disruptions in circadian rhythms across an organism are associated with negative health outcomes, such as cardiometabolic and neurodegenerative diseases. Exercise has been proposed as a time cue for the circadian clock in rodents and humans. In this study, we assessed the effect of a single bout of endurance exercise on the skeletal muscle clock in vivo and a bout of muscle contractions in vitro. Timing of exercise or contractions influences the directional response of the muscle clock phase in vivo and in vitro. Our findings demonstrate that muscle contractions, as a component of exercise, can directly modulate the expression of muscle clock components in a time-of-day dependent manner.

Abstract

Exercise has been proposed to be a zeitgeber for the muscle circadia

SUBMITTER: Kemler D 

PROVIDER: S-EPMC7479806 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature