Mild inflammation causes a reduction in resting-state amplitude of low-frequency fluctuation in healthy adult males.

ABSTRACT: Systemic inflammation has been associated with negative mood states and human sickness behaviour. Previous studies have shown an association between systemic inflammation and changes in task-related blood-oxygen-level-dependent activity and functional connectivity within large-scale networks. However, no study has examined the effect of inflammation on the magnitude of blood-oxygen-level-dependent low-frequency fluctuations at rest. We used a double-blind placebo-controlled crossover design to randomise 20 male subjects (aged 20-50 years) to receive either a Salmonella typhi vaccine or a placebo saline injection at two separate sessions. All participants underwent a resting-state functional magnetic resonance scan and a measure of inflammation (interleukin 6) and mood (Profile of Mo

SUBMITTER: Stefanov K 

PROVIDER: S-EPMC7479852 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature