Impairments in sensory-motor gating and information processing in a mouse model of Ehmt1 haploinsufficiency.

ABSTRACT: Regulators of chromatin dynamics and transcription are increasingly implicated in the aetiology of neurodevelopmental disorders. Haploinsufficiency of EHMT1, encoding a histone methyltransferase, is associated with several neurodevelopmental disorders, including Kleefstra syndrome, developmental delay and autism spectrum disorder. Using a mouse model of Ehmt1 haploinsufficiency (Ehmt1 ^D6Cre/+), we examined a number of brain and behavioural endophenotypes of relevance to neurodevelopmental disorders. Specifically, we show that Ehmt1 ^D6Cre/+ mice have deficits in information processing, evidenced by abnormal sensory-motor gating, a complete absence of object recognition memory, and a reduced magnitude of auditory evoked potentials in both pai

SUBMITTER: Davis BA 

PROVIDER: S-EPMC7479861 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature