The Potential Role of Extracellular Vesicles in COVID-19 Associated Endothelial injury and Pro-inflammation.

ABSTRACT: COVID-19 infection caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic with the number of deaths growing exponentially. Early evidence points to significant endothelial dysfunction, micro-thromboses, pro-inflammation as well as a dysregulated immune response in the pathogenesis of this disease. In this study, we analyzed the cargo of EVs isolated from the plasma of patients with COVID-19 for the identification of potential biomarkers of disease severity and to explore their role in disease pathogenesis. Plasma-derived EVs were isolated from 53 hospitalized patients with COVID infection and compared according to the severity of the disease. Analysis of inflammatory and cardiovascular protein cargo of large EVs revealed significa

SUBMITTER: Krishnamachary B 

PROVIDER: S-EPMC7480053 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature