Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside.

ABSTRACT: Organic solute transporter alpha/beta (OSTα/β) is a heteromeric solute carrier protein that transports bile acids, steroid metabolites and drugs into and out of cells. OSTα/β protein is expressed in various tissues, but its expression is highest in the gastrointestinal tract where it facilitates the recirculation of bile acids from the gut to the liver. Previous studies established that OSTα/β is upregulated in liver tissue of patients with extrahepatic cholestasis, obstructive cholestasis, and primary biliary cholangitis (PBC), conditions that are characterized by elevated bile acid concentrations in the liver and/or systemic circulation. The discovery that OSTα/β is highly upregulated in the liver of patients with nonalcoholic steatohepatitis (NASH) further highlights the clinical releva

SUBMITTER: Beaudoin JJ 

PROVIDER: S-EPMC7480074 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature