Klotho (rs1207568 and rs564481) gene variants and colorectal cancer risk.

ABSTRACT:

Background/aims

Whereas colorectal cancer (CRC) is the third most common cancer worldwide, klotho gene has been reported as a tumor suppressor gene. Therefore, the aim of this study was to investigate the association between klotho (rs1207568 and rs564481) variants and CRC in Egyptian patients.

Materials and methods

A case-control study comprising 100 patients with CRC and 100 age- and sex-matched healthy controls was conducted. Genotyping of klotho was performed by polymerase chain reaction with confronting two-pair primers.

Results

The frequencies of the A allele of rs1207568 and the AC haplotype were significantly higher in patients with CRC than in the controls (p=0.019 and p=0.005, respectively).

Conclusion

We propose that klotho (rs1207568 and rs564481) v

SUBMITTER: Kamal A 

PROVIDER: S-EPMC7480194 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature