Multi-centre, multi-vendor reproducibility of 7T QSM and R₂* in the human brain: Results from the UK7T study.

ABSTRACT:

Introduction

We present the reliability of ultra-high field T₂* MRI at 7T, as part of the UK7T Network's "Travelling Heads" study. T₂*-weighted MRI images can be processed to produce quantitative susceptibility maps (QSM) and R₂* maps. These reflect iron and myelin concentrations, which are altered in many pathophysiological processes. The relaxation parameters of human brain tissue are such that R₂* mapping and QSM show particularly strong gains in contrast-to-noise ratio at ultra-high field (7T) vs clinical field strengths (1.5-3T). We aimed to determine the inter-subject and inter-site reproducibility of QSM and R₂* mapping at 7T, in readiness for future multi-site clinical studies.

Methods

Ten healthy volunteers were

SUBMITTER: Rua C 

PROVIDER: S-EPMC7480266 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature