Effect of Ferric Citrate versus Ferrous Sulfate on Iron and Phosphate Parameters in Patients with Iron Deficiency and CKD: A Randomized Trial.

ABSTRACT:

Background and objectives

Ferric citrate is an oral medication approved for treatment of iron deficiency anemia in patients with CKD not requiring dialysis. The relative efficacy of ferric citrate versus ferrous sulfate in treating iron deficiency in patients with CKD is unclear.

Design, setting, participants, & measurements

We randomized 60 adults with moderate to severe CKD (eGFR 15-45 ml/min per 1.73 m²) and iron deficiency (transferrin saturation [TSAT] ≤30% and ferritin ≤300 ng/ml) to ferric citrate (2 g three times a day with meals, n=30) or ferrous sulfate (325 mg three times a day, n=30) for 12 weeks. Primary outcomes were change in TSAT and ferritin from baseline to 12 weeks. Secondary outcomes were change in hemoglobin, fibroblast growth fa

SUBMITTER: Womack R 

PROVIDER: S-EPMC7480557 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature