Axillary Response in Patients Undergoing Neoadjuvant Endocrine Treatment for Node-Positive Breast Cancer: Systematic Literature Review and NCDB Analysis.

ABSTRACT:

Background

Several studies have proven that neoadjuvant endocrine therapy (NET) has a similar beneficial therapeutic effect in estrogen-positive (ER⁺) breast cancer (BC) with improved breast conservation rate in patients undergoing NET versus neoadjuvant chemotherapy (NAC). The impact of axillary complete pathologic response (pCR) is less clear. We evaluate the impact of NET on axillary downstaging and surgical management.

Methods

Using the National Cancer Database (NCDB), we identified all patients with node positive (N⁺), ER⁺, HER^2- BC undergoing NET and performed a systemic review of literature using PRISMA guidelines.

Results

The literature review identified 1479 clinically N⁺ patients in four studies, 148 of

SUBMITTER: Stafford A 

PROVIDER: S-EPMC7480656 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature