Heterogeneity in lobar and near-acini deposition of inhaled aerosol in the mouse lung.

ABSTRACT: Laboratory animals are often used to derive health risk from environmental exposure or to assess the therapeutic effect of a drug delivered by inhaled therapy. Knowledge of the in-situ distribution of deposited particles on airway and alveolar surfaces is essential in any assessment of these effects. A unique database including both high-resolution lung anatomy and deposition data in four strains of laboratory mice have been recently made publicly available to the research community (https://doi.org/10.25820/9arg-9w56). Using these data, we investigated the effect of particle size on the distribution of deposited particles at the lobar and near-acini level. Analysis was performed on a total of 33 mice where 3, 16 and 14 animals were exposed to 0.5μm, 1μm and 2μm particles, respectively. Ra

SUBMITTER: Gu W 

PROVIDER: S-EPMC7480823 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature