Education, intelligence, and amyotrophic lateral sclerosis: A Mendelian randomization study.

ABSTRACT:

Objective

To systematically investigate causal relationships between educational attainment, cognitive-related phenotypes, and amyotrophic lateral sclerosis (ALS).

Methods

Summary statistics from genome-wide association studies for educational attainment, math ability, highest math class taken, cognitive performance, intelligence, and ALS were used. A two-sample Mendelian randomization (MR) design was applied to explore the potential causal associations between them.

Results

Genetically predisposition to longer educational attainment and harder math class taken were associated with significantly lower statistical odds ratio of ALS. For per year increase in education completed there was a 21% lower (95% confidence interval [CI] = 27-14%) in risk for ALS. For per 1-SD i

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7480912 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature