Validation of differentially expressed brain-enriched microRNAs in the plasma of PD patients.

ABSTRACT:

Objective

There is a pressing need to identify and validate, minimally invasive, molecular biomarkers that will complement current practices and increase the diagnostic accuracy in Parkinson's disease (PD). Brain-enriched miRNAs regulate all aspects of neuron development and function; importantly, they are secreted by neurons in amounts that can be readily detected in the plasma. Τhe aim of the present study was to validate a set of previously identified brain-enriched miRNAs with diagnostic potential for idiopathic PD and recognize the molecular pathways affected by these deregulated miRNAs.

Methods

RT-qPCR was performed in the plasma of 92 healthy controls and 108 idiopathic PD subjects. Statistical and in silico analyses were used to validate deregulated miRNAs and pathwa

SUBMITTER: Ravanidis S 

PROVIDER: S-EPMC7480914 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature