Association of MAPT subhaplotypes with clinical and demographic features in Parkinson's disease.

ABSTRACT:

Objective

To determine whether distinct microtubule-associated protein tau MAPT H1 subhaplotypes are associated with clinical and demographic features in Parkinson's disease.

Methods

A retrospective cohort study included 855 unrelated Caucasian patients with Parkinson's disease who were seen by Movement Disorder specialists at the Mayo Clinic Florida between 1998 and 2016. The primary outcome measures were specific demographic and clinical features of Parkinson's disease, including age at onset, disease progression, survival, motor signs, dementia, dystonia, dyskinesia, autonomic dysfunction, impulse control disorder, psychiatric features, REM sleep behavior disorder, restless legs syndrome, and Parkinson's disease subtype. Specific clinical features were measured at the ini

SUBMITTER: Deutschlander AB 

PROVIDER: S-EPMC7480915 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature